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KMID : 0370019900040000079
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Chung-Ang Journal of Pharmacal Sciences
1990 Volume.4 No. 0 p.79 ~ p.87
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Synthesis of Quinolone-3-Carboxylic Acids Antimicrobial Agents
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Abstract
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In an effort to find more potent antimicrobial substances, eight bivalent ligands containing enoxacin pharmacophore were prepared and evaluated for their antimicrobial activities. Theatment of enoxacin[1-ethyl-6-fluoro- 1.4-dihydro- 4-oxo-7-(1-piperdzinyl)-1.8-naphthyridine- 3-carboxylic acid] with active ester of alkane (or alkene) dioyl bisoligoglycine afforded eight dicarboxylic acid bis(oligoglycyl enoxacin)s. As a result of this study, N.N´-oxalyl bis(glycyl enoxacin) (1) and N · N´-malongylbis(glycyl enoxacin) (2) were found to show the most potent in vitro antibacterial activities.
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